During the early 5th century, a big unusual building was erected in the middle of the central court: the Tetraconch. A tetraconch is a building with four apses, one in each direction and is usually related to a christian church. However, it seems that initially, this building in Athens was used as an administrative edifice and was probably later on converted into a church.
Parts of various destroyed buildings were used for its construction, including blocks of the Pantheon and pier shafts from the Odeon of Agrippa.
The building consisted of a big central hall in the form of a square with each side measuring 15,42m. Each side had a semi-circular apse. The three apses had a double colonade which supported a floor looking over the main hall. The eastern apse had 3 large windows. Towards the west, and next to the main hall there was a series of rooms, two of which contained the staircase leading to the upper floor. Further to the west there was an atrium surrounded by columns.
The tetraconch was destroyed in the 6th century and was replaced by a smaller basilica dedicated to St. Mary, called Megali Panagia (Great Mary), which was burned in the 11th century. Finally, a third very small church was built over the last one in the 12th century.